Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives

Objective: A new series of 4-[3-(substitutedphenyl)thioureido]-N-(6-chloropyrazin-2-yl)benzenesulfonamide were synthesized from sulfaclozine. Methods: All compounds characterized by IR, 1H-NMR spectroscopic methods and elemental analysis. In addition to the antioxidant activity synthesis series, enzyme inhibition activities such as anticholinesterase, tyrosinase, ?-amylase ?-glycosidase determined for first time in this study. Results: According these biological test results, compound 2a DPPH, 2c ABTS?+ assay exhibited more than reference standard. thiourea derivatives demonstrated good BChE inhibitory galantamine. Among compounds, 2e 2f showed best tyrosinase activity, while 2g had ?-glucosidase activity. addition, we evaluated druglikeness properties their oral bioavailability also found be high. Conclusion: Thiourea remarkable against cholinesterase, ?-glucosidase.